FXR and GPBAR1 signaling in the vascular system and liver in MASLD. A recent study published by JAHA 2023 highlights a role of bile acids in liver steatohepatitis and atherosclerosis
Vascular injury linked to metabolic dysfunction-associated steatotic liver disease (MASLD) By Stefano Fiorucci, MD and others
Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G‐Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease
Silvia Marchianò, Michele Biagioli, Martina Bordoni, Elva Morretta, Cristina Di Giorgio, Valentina Vellecco, Rosalinda Roselli, Rachele Bellini, Carmen Massa, Luigi Cari, Ginevra Urbani, Patrizia Ricci, Maria Chiara Monti, Antonino Giordano, Vincenzo Brancaleone, Mariarosaria Bucci, Angela Zampella, Eleonora Distrutti, Enrico Cieri, Giuseppe Cirino and Stefano Fiorucci
Originally published23 Nov 2023https://doi.org/10.1161/JAHA.123.031241Journal of the American Heart Association. 2023;12:e031241
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